Hamish Watson will return from injury to earn his 50th Scottish cap in Saturday’s second Test in Argentina.
The flanker replaces Edinburgh team-mate Luke Crosbie in the line-up for the encounter in Salta.
Gregor Townsend made five changes in all after a 26-18 loss in the first Test.
Ben White replaces Ali Price as scrum-half to make his first start for Scotland. The Irish player from London made his debut against England earlier this year and earned his fifth cap from the bench at Jujuy last Saturday.
Dave Cherry, Sam Skinner and Rory Darge enter the peloton, along with Watson.
Edinburgh hooker Cherry is back in the squad for the first time since playing in all five Six Nations games in Scotland in 2021, in a direct exchange for George Turner, who falls to the bench.
The New Edinburgh signing Skinner replaces Jonny Gray and will wear the number four shirt alongside captain Grant Gilchrist in the second row.
Darge returned from injury on the bench in the first Test and will make his fourth start for Scotland, with the 22-year-old replacing Magnus Bradbury in the back row.
Bradbury, Crosbie and Gray leave Townsend’s squad on matchday, while London winger Kyle Rowe could make his debut on the bench.